After a number of frustrating hours trying to get turbogears to run through mod_python in apache and not getting very far, I ended up at the cherrypy website where they recommend deploying it using mod_proxy. This works quite well and was nice any easy to setup. It works by simply running your turbogears application on some port and then having apache direct requests (proxy) to the port that the turbogears application is running. The following documention covers how to set it up: